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Paul McGlothin is president of The CR Way Longevity Center. Meredith Averill is program director. Paul started studying chemistry at age 9, having a pint-sized lab beside his father's who was an outstanding clinical researcher in pharmacology. Paul's avid work with his dad through high-school and college chemistry books was augmented by visits to the chemistry laboratories at the University of Tennessee. Meredith waited until high school to fall in love with the biosciences: She and a friend designed their own field trips and became lab assistants the very next year. She went on to study in such related fields as chemistry, microbiology, anatomy, physiology, and nutrition. When they met, they noticed right away how strongly they shared the common goal of achieving and maintaining great health.

Their enthusiasm for in science, diet, and lifestyle leapt forward when Paul's doctor introduced him to calorie restriction as a way of raising his level of health and possibly achieving significant life extension. Soon Paul and Meredith, who chairs the CR Society Intl's board of directors, assembled a team of doctors to help them sort out fact from fiction, testing clinical outcomes of their calorie-restricted diet.

To help better understand what to expect from human calorie restriction, they collaborated with MetaMetrix Clinical Laboratory in Atlanta to create the first study of long-term calorie restriction in humans. Subsequently, they helped assemble the human cohort for studies with Drs. Luigi Fontana and John Holloszy and their colleagues at the Washington University in Saint Louis School of Medicine, which has grown into the first longitudinal study of the effects of human calorie restrictors who have been limiting calories with a focus on optimal nutrition. In addition to contributions to project planning, both Paul and Meredith participate as study subjects.

During this period the two also worked with a variety of labs on multiple projects, including testing the beneficial effects of maintaining low circulating blood glucose, studying the effect on the lipid profile of taking in various fats, and creating a pilot study on Resveratrol that was reported at the 2004 CR Society Conference. Paul's outstanding work in testing and reporting CR results and helping create calorie restriction research projects led to his being named Research VP of the CR Society, where he works with scientists to plan studies and also serves on the Society's board of directors.

In 2009, the husband-and-wife team was asked to help plan and create, a human CR research project — CRONA (Calorie Restriction with Optimal Nutrition and Aging): A Milestone Study To Look at the Genetic Effects of CR in a Human Cohort of Long-Term CR, by comparing readings to age-and sex-matched controls. The research team includes many world-famous researchers:

1.      Elizabeth Blackburn (Biophysics and Biochemistry, UCSF)

2.     Anne Brunet (Genetics, Stanford)

3.     Elissa Epel (Psychiatry, UCSF)

4.     Pankaj Kapahi (Buck Institute for Age Research)

5.     Cynthia Kenyon, (Biophysics and Biochemistry, UCSF)

6.     Jue Lin (Biochemistry & Biophysics, UCSF)

7.     Eric Verdin (Gladstone Institute of Virology and Immunology and UCSF)

All through their 19 years of CR practice, PauP&M_with_book.jpgl & Meredith have enjoyed extraordinary physical and mental health, as demonstrated by their energy and how great they feel, as well as by their lab  results. They wrote the Amazon best-seller, The CR Way: Using the Secrets of Calorie Restriction for a Longer, Healthier Life, published in 2008 by HarperCollins and launched on Barbara Walters' longevity special, "Living to Be 150: Can You Do It?" In 2009, they co-created a new CR communication medium, The CR Way to Happy Dieting, an online resource that integrates film, podcasts, and flash technology to serve as a quick-start guide for anyone who wants to practice CR and to members of Sharing the CR Way™ is their passion.

Recognizing that CR Way followers need advanced nutrition and fitness software to gain the most from their lifestyle, the authors collaborated with Ed Prestwood of NutriBase to create NutriBase CR Way Edition software.
Paul & Meredith have been featured
on the BBC, Good Morning America, Today, FoxNews, NBC Nightly News, ABC News, 20/20, CBS News The Early Show, 60 Minutes, NHK (Japanese Broadcasting Corp.), German public television, Australian 60 Minutes, as well as in New York magazine, Fortune, and other publications. Radio appearances are too numerous to list.

Paul McGlothin and Meredith Averill are a bridge: translating the research into application. The CR Way "diet" is based on decades of research, e.g., at the National Institute on Aging, Harvard University, Washington University,  the University of California, San Francisco, and their own testing. They welcome all to join them. In fact, they have opened The CR Way Longevity Center in Westchester County, NY, the first bricks-and-mortar location that CR practitioners can call their own.